Noradrenaline Bitartrate Injection
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Noradrenaline is a sympathomimetic amine, which acts predominantly by a direct effect on alphaadrenergic receptors. The drug also directly stimulates the betaadrenergic receptors of the heart (beta1- adrenergic receptors), but not those of the bronchi (beta2-adrenergic receptors). Noradrenaline functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). These actions result in an increase in the force of myocardial contraction, increase in peripheral resistance and a rise in diastolic and systolic pressures.
Is used for restoration of blood pressure in acute hypotensive states.
Mode of action:
Norepinephrine is synthesized from tyrosine as a precursor, and packed into synaptic vesicles. It performs its action by being released into the synaptic cleft, where it acts on adrenergic receptors, followed by the signal termination, either by degradation of norepinephrine or by uptake by surrounding cells.